Gene
gata3
- ID
- ZDB-GENE-990415-82
- Name
- GATA binding protein 3
- Symbol
- gata3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; fin regeneration; and positive regulation of neuron migration. Acts upstream of or within cardiac muscle tissue regeneration; embryonic organ morphogenesis; and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; ectoderm; nervous system; neural tube; and pleuroperitoneal region. Used to study hypoparathyroidism-retardation-dysmorphism syndrome. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 91 figures from 58 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb550 (29 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gata3 | (2) | |
| CRISPR2-gata3 | Swartz et al., 2021 | |
| MO1-gata3 | N/A | (9) |
| MO2-gata3 | N/A | (2) |
| MO3-gata3 | N/A | Kwon et al., 2010 |
| MO4-gata3 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypoparathyroidism-deafness-renal disease syndrome | Alliance | Hypoparathyroidism, sensorineural deafness, and renal dysplasia | 146255 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BC31 | InterPro | 384 | ||||
| UniProtKB:Q91428 | InterPro | 438 | ||||
| UniProtKB:A0A8M2BC50 | InterPro | 403 | ||||
| UniProtKB:B3DGG5 | InterPro | 438 | ||||
| UniProtKB:A0A8M9Q5R9 | InterPro | 382 | ||||
| UniProtKB:A0A8M2BC08 | InterPro | 419 |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-268B12 | ZFIN Curated Data | |
| Encodes | EST | cb550 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:194063 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194082 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131211 (1) | 2576 nt | ||
| Genomic | GenBank:BX901908 (2) | 210697 nt | ||
| Polypeptide | UniProtKB:B3DGG5 (1) | 438 aa |
- Park, G., Foster, C.A., Malone-Perez, M., Hasan, A., Macias, J.J., Frazer, J.K. (2024) Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method. Journal of immunology (Baltimore, Md. : 1950). 213(12):1902-1914
- Bu, L.K., Jia, P.P., Li, W.G., Li, Y.Z., Li, T.Y., Pei, D.S. (2023) Probiotics mitigate kidney damage after exposure to Sri Lanka's local groundwater from chronic kidney disease with uncertain etiology (CKDu) prevalent area in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 262:106671106671
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Hadzhiev, Y., Wheatley, L., Cooper, L., Ansaloni, F., Whalley, C., Chen, Z., Finaurini, S., Gustincich, S., Sanges, R., Burgess, S., Beggs, A., Müller, F. (2023) The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation. Developmental Cell. 58:155170.e8155-170.e8
- Kar, R.D., Eberhart, J.K. (2023) Predicting Modifiers of Genotype-Phenotype Correlations in Craniofacial Development. International Journal of Molecular Sciences. 24(2):
- Liu, X., Zhou, L., Li, W., Wu, J., Wang, D. (2023) Gata2a Mutation Causes Progressive Microphthalmia and Blindness in Nile Tilapia. International Journal of Molecular Sciences. 24(4):
- Wang, H., Zaiser, F., Eckert, P., Ruf, J., Kayser, N., Veenstra, A.C., Müller, M., Haas, R., Walz, G., Yakulov, T.A. (2023) Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Biochemical and Biophysical Research Communications. 673:9159-15
- Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
- Barker, C.M., Miles, K.D., Doll, C.A. (2022) Fmrp regulates neuronal balance in embryonic motor circuit formation. Frontiers in neuroscience. 16:962901
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